Ceftazidime-avibactam-resistant Klebsiella pneumoniae driven by multiple β-lactamase mutation: a hospital outbreak report - PubMed
4 hours ago
- #Antimicrobial Resistance
- #Nosocomial Infection
- #Klebsiella pneumoniae
- Study traces clonal dissemination of ceftazidime-avibactam-resistant Klebsiella pneumoniae.
- Identifies resistance mechanism via novel variant CTX-M-249, which evades avibactam inhibition.
- Resistance genes evolved under ceftazidime-avibactam selective pressure, enhancing resistance through gene duplication.
- Highlights a nosocomial outbreak with strains showing less than six SNPs apart, indicating clonal spread.
- Emphasizes the need for global infection control measures against such resistant strains.