Association between multiple inflammatory indices and gout: a cross-sectional study based on clinical and NHANES data - PubMed
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- #inflammatory markers
- #NHANES
- #gout
- Study investigates the association between systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and gout.
- Gout patients and non-gout participants were recruited from a hospital and the NHANES database (2007-2016).
- Significant differences found in gender, age, education, BMI, smoking, alcohol consumption, hypertension, and diabetes between gout patients and healthy controls.
- Male patients, older age, low education, smoking, drinking, diabetes, high neutrophil, monocyte, platelet counts, and high SII/SIRI are risk factors for gout.
- Lymphocyte and platelet counts negatively correlated with serum uric acid levels; neutrophil count, monocyte count, and SIRI positively correlated.
- Results validated through NHANES database analysis.
- SII and SIRI are positively correlated with a high risk of gout and can serve as novel inflammatory markers for gout.