A Ginkgo biloba-derived tRNA-derived fragment attenuates asthma by restoring airway structural cell homeostasis via mitochondrial regulation - PubMed
6 hours ago
- #Mitochondrial Function
- #Traditional Chinese Medicine
- #Asthma
- A tRNA-derived fragment (tRF) from Ginkgo biloba, named tRF_G6, reduces asthma symptoms.
- tRF_G6 targets the protein PMEPA1, which is involved in airway remodeling.
- By inhibiting PMEPA1, tRF_G6 restores mitochondrial function and reduces inflammation in airway cells.
- The study used both mouse models and human cell lines to validate the therapeutic effects.
- Findings highlight the potential of traditional Chinese medicine-derived nucleic acids for asthma treatment.