Targeting the cGAS-STING pathway in ophthalmology: from innate immunity to therapeutic innovation - PubMed
4 hours ago
- #ophthalmology
- #therapeutic innovation
- #innate immunity
- The cGAS-STING pathway is a key mediator of innate immune response to cytosolic DNA.
- Abnormal activation of the cGAS-STING pathway is linked to various ocular diseases including age-related macular degeneration, diabetic retinopathy, corneal injuries, glaucoma, and ocular tumors.
- The pathway plays roles in ocular inflammation, tissue degeneration, fibrosis, angiogenesis, and immune surveillance.
- Mechanistic insights into how cGAS-STING orchestrates pathological processes across different ocular compartments are discussed.
- Interactions with autophagy, cellular senescence, and cell death highlight its potential as a therapeutic target.
- Future research directions focus on exploiting cGAS-STING modulation for precision therapies in vision-threatening diseases.