Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications - PubMed
7 hours ago
- #immune regulation
- #pulmonary fibrosis
- #autoantibody
- RA-ILD is a common extra-articular manifestation of rheumatoid arthritis, potentially leading to progressive pulmonary fibrosis and severe outcomes.
- Key contributors include genetic susceptibility, environmental factors, immune dysregulation, autoantibodies, adaptive immune abnormalities, tertiary lymphoid organs, pro-inflammatory cytokines, and epithelial-mesenchymal transition.
- Current treatments like glucocorticoids, immunosuppressants, and antifibrotic agents have side effects; emerging therapies such as JAK inhibitors, CAR-T cells, and nerandomilast show promise but no cure exists.
- Future research may focus on multi-omics technologies and multicenter clinical trials for therapeutic targets and precision medicine.