The dual roles of natural cannabidiol in combating oxidative stress and inflammation: A potential intestinal guardian - PubMed
2 days ago
- #Cannabidiol
- #Oxidative Stress
- #Inflammation
- Cannabidiol (CBD) is a non-psychoactive, non-addictive compound from Cannabis sativa L. with therapeutic potential for intestinal diseases.
- CBD has antioxidant and anti-inflammatory effects in the gastrointestinal tract, addressing oxidative stress and inflammation.
- Oxidative stress and redox imbalance contribute to epithelial barrier dysfunction and diseases like inflammatory bowel disease (IBD) and colorectal cancer (CRC).
- CBD regulates reactive oxygen species (ROS), activates the Nrf2-Keap1 antioxidant pathway, and modulates inflammatory signaling (NF-κB, NLRP3 inflammasome).
- CBD interacts with the endocannabinoid system (ECS) to protect the epithelial barrier, regulate gut microbiota, and reduce oxidative stress and inflammation.
- CBD's effects extend to systemic impacts via the gut-organ axis, including gut-brain and gut-liver interactions.
- The review highlights CBD's combined roles in redox modulation, inflammation control, and intestinal barrier protection for disease management.