Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment - PubMed
5 hours ago
- #tumor microenvironment
- #Hodgkin lymphoma
- #Epstein-Barr virus
- Epstein-Barr virus (EBV) is present in about 25% of classic Hodgkin lymphoma (cHL) cases, contributing to tumor microenvironment (TME) reorganization.
- EBV-positive cHL shows distinct immune features, including memory CD8 T cell enrichment and heightened T cell dysfunction near Hodgkin and Reed-Sternberg (HRS) cells.
- EBV-encoded LMP1 promotes T cell dysfunction via enhanced HRS-CD8 interactions, with its expression correlating with terminal T cell exhaustion in a distance-dependent manner.
- The study uses spatial proteomics and transcriptomics to map EBV-linked TME changes, revealing potential therapeutic targets for virus-associated malignancies.
- EBV-negative cHL exhibits progenitor-exhausted T cell patterns, contrasting with terminally exhausted signatures in EBV-positive cases.