Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism - PubMed
a day ago
- #cardiac metabolism
- #SCN5A
- #mitochondrial function
- SCN5A encodes the cardiac NaV1.5 channel, involved in action potentials and cardiomyocyte metabolism.
- A novel alternative polyadenylation (APA) signal downstream of SCN5A exon 2 was identified, producing a truncated transcript (SCN5A-short).
- SCN5A-short encodes NaV1.5-NT, a mitochondrial-targeted peptide influencing cardiac metabolism.
- NaV1.5-NT enhances mitochondrial respiration, ATP production, and alters complex I and V activities.
- Reduced SCN5A-short expression is observed in failing human hearts, suggesting metabolic implications in heart failure.