Evidence of White Matter Neuroinflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Diffusion-Based Neuroinflammation Imaging Study - PubMed
4 hours ago
- #ME/CFS
- #white matter abnormalities
- #neuroinflammation
- Study provides in vivo evidence of white matter neuroinflammation in ME/CFS using advanced diffusion-based neuroinflammation imaging (NII).
- ME/CFS patients showed widespread white matter abnormalities compared to healthy controls, including changes in NII-derived metrics like NII-HR, NII-RF, and NII-FF.
- Lower NII-RF, NII-AD, and NII-MD in ME/CFS were associated with worse mental health, while lower NII-RF correlated with higher disability levels.
- Higher NII-FF in ME/CFS patients was linked to lower disease severity.
- Conventional DTI showed minimal differences between groups and no significant clinical associations.
- Findings suggest NII-derived indices could serve as sensitive biomarkers for neuroinflammation in ME/CFS.