Wheat Flour Intake Promotes Weight Gain and Metabolic Changes in Mice - PubMed
2 hours ago
- #obesity
- #wheat flour
- #metabolomics
- Mice showed strong preference for wheat-based foods leading to significant weight gain, despite similar calorie intake.
- Wheat flour consumption reduced energy expenditure, increased fat accumulation, and raised insulin and leptin levels.
- Metabolomic analysis indicated higher fatty acids and lower essential amino acids, suggesting enhanced lipogenesis.
- Liver genes for fatty acid synthesis and lipid transport were upregulated with wheat intake.
- Stopping wheat flour quickly reversed weight gain and metabolic changes, highlighting its role in obesity.