Accelerated biological aging is associated with the negative relationship between dietary intake of live microbes and diabetic retinopathy in US diabetic patients - PubMed
4 hours ago
- #biological aging
- #diabetic retinopathy
- #dietary live microbes
- Higher dietary intake of live microbes is associated with a lower risk of diabetic retinopathy (DR) in US diabetic patients.
- The study categorized participants into low, medium, and high live microbe intake groups, showing reduced DR risk with higher intake (OR = 0.58 for high vs. low).
- A nonlinear dose-response relationship was found, with an inflection point at 262.86 g/day of live microbe intake.
- Biological aging markers (PhenoAge and KDM-BA acceleration) and glycemic control (HbA1c) partially mediated the relationship between live microbe intake and DR.
- Subgroup analysis indicated the association was consistent across most subgroups, with a significant interaction only in the sex subgroup.
- The study suggests increasing intake of live microbe-rich foods may help reduce DR risk, highlighting the potential role of biological aging and glycemic control in this relationship.