Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies - PubMed
7 hours ago
- #extracellular vesicles
- #oxidative stress
- #ovarian aging
- Ovarian aging is influenced by oxidative stress, mitochondrial dysfunction, and chronic inflammation.
- Environmental and lifestyle factors like smoking, high-fat diets, and endocrine-disrupting chemicals accelerate ovarian decline.
- Redox imbalance and mitochondrial impairment are key drivers of follicular depletion and endocrine dysfunction.
- Current antioxidant strategies include melatonin, N-acetylcysteine, coenzyme Q10, polyphenols, and vitamins C and E.
- Stem cell-derived extracellular vesicles (EVs) show promise in reducing oxidative stress and restoring ovarian function.
- EV-based therapies may extend reproductive healthspan by supporting mitochondrial function and ovarian physiology.