Lipid Metabolism and Neurodegeneration: Mechanistic Insights and Therapeutic Targets - PubMed
2 days ago
- #Lipid Metabolism
- #Neurodegeneration
- #Therapeutic Targets
- Lipid metabolism is crucial for brain homeostasis, influencing energy balance, membrane structure, and signaling for neuronal and glial health.
- Disruptions in lipid pathways are linked to neuroinflammation and progression of neurodegenerative diseases like Alzheimer's and Parkinson's, as well as aging.
- Changes in cholesterol trafficking, sphingolipid/ceramide metabolism, and phospholipid remodeling can compromise synaptic integrity and increase oxidative stress and inflammation.
- Advanced techniques like scRNA-seq and single-nucleus transcriptomics reveal lipid metabolism alterations across cell types, indicating metabolic shifts that enhance microglial activation and astrocytic reactivity.
- Lipid dysregulation creates a cycle heightening neuronal vulnerability; lipid rafts facilitate receptor-mediated signaling, tying imbalances to immune activation.
- Therapeutic strategies targeting lipid pathways include modulating apolipoprotein E, inhibiting ceramide synthesis, and supplementing fatty acids to enhance membrane fluidity.
- Lipidomics helps identify unique lipid signatures as potential biomarkers for early diagnosis and treatment monitoring, offering insights for targeted interventions.