ETV4 Khib Promotes Intrahepatic Cholangiocarcinoma Progression by Suppressing Ferroptosis Through TXNIP Downregulation - PubMed
8 hours ago
- #Cholangiocarcinoma
- #Ferroptosis
- #ETV4
- ETV4 K97-Khib modification is significantly upregulated in intrahepatic cholangiocarcinoma (ICC) and linked to tumor metastasis and poor patient outcomes.
- ETV4 K97-Khib promotes ICC progression by enhancing ferroptosis resistance through dual suppression of TXNIP (transcriptional repression and SUMOylation-mediated degradation).
- KAT2A and HDAC1 regulate ETV4 Khib dynamics, acting as acyltransferase and deacylase, respectively.
- Thiostrepton, a small-molecule compound, inhibits ETV4 K97-Khib, promoting ferroptosis and reducing ICC cell migration, invasion, and metastasis.
- The study identifies ETV4 Khib as a novel therapeutic target for ICC by modulating ferroptosis suppression.