Neutrophil Extracellular Traps in Diabetic Kidney Disease: Mechanisms of Pathogenesis and Emerging Therapeutic Strategies - PubMed
3 hours ago
- #NETosis
- #Diabetic Kidney Disease
- #Therapeutic Targets
- Diabetic kidney disease (DKD) is a major complication of diabetes and a leading cause of end-stage renal disease globally.
- Neutrophil extracellular trap (NET) formation (NETosis) is a key mechanism linking metabolic stress to immune dysregulation in DKD.
- Hyperglycemia, AGEs, protein kinase C signaling, lipid abnormalities, and pro-inflammatory cytokines promote excessive NETosis in diabetes.
- NETs contribute to renal injury by causing endothelial dysfunction, podocyte damage, macrophage activation, and fibrosis.
- Emerging therapeutic strategies target NETosis, including PAD4 inhibitors, NADPH oxidase inhibitors, and NET-degrading agents like DNase I.
- Classic antidiabetic drugs like metformin and GLP-1 receptor agonists may also modulate NET formation.
- NETosis is both a potential biomarker and therapeutic target in DKD.