Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System - PubMed
3 hours ago
- #aging
- #lung organoid
- #senescence
- The study focuses on modeling the aging human lung by creating a senescent human lung organoid culture system.
- Senescence in the aging lung leads to chronic inflammation and fibrosis, contributing to diseases like COPD and IPF.
- Researchers generated a human iPSC-derived lung organoid system, inducing senescence with doxorubicin.
- Senescent cells showed increased β-galactosidase activity, pro-inflammatory cytokine production, and impaired barrier integrity.
- The model replicates key aspects of lung senescence, useful for studying age-related lung diseases and potential treatments.