BMP-Smad1/9 signaling plays a critical role in regulating zebrafish PGC proliferation - PubMed
4 hours ago
- #zebrafish
- #BMP-Smad1/9
- #primordial germ cells
- BMP-Smad1/9 signaling is crucial for zebrafish primordial germ cell (PGC) maintenance, not fate determination.
- Inhibition of BMP signaling or knockdown of smad1/9 reduces PGC numbers in zebrafish.
- PGC-specific smad1/9 knockouts show impaired PGC proliferation and increased apoptosis.
- Transcriptome analysis reveals upregulation of DNA damage response-related genes in PGCs upon smad1/9 deficiency.
- ATR inhibition can restore PGC numbers, indicating a link between BMP-Smad1/9 signaling and DNA damage response in PGCs.
- The study highlights conserved but functionally distinct roles of BMP signaling in vertebrate PGC development.