Glyphosate promotes calcium oxalate crystal-induced renal injury by modulating the PI3K/Akt-mediated mechanism - PubMed
4 days ago
- #PI3K/AKT pathway
- #Glyphosate
- #Nephrolithiasis
- Glyphosate exposure is linked to an increased risk of nephrolithiasis (kidney stones) in a dose-dependent manner.
- Each unit increase in log-transformed glyphosate concentration raises nephrolithiasis risk by 25% (OR = 1.25, 95% CI: 1.06-1.47).
- Network toxicology and molecular docking identified the PI3K/AKT signaling pathway as a key target of glyphosate.
- Glyphosate exacerbates calcium oxalate-induced renal injury, oxidative stress, and apoptosis by suppressing the PI3K/AKT pathway.
- The adverse effects of glyphosate on kidney health can be reversed by activating the PI3K/AKT pathway.
- This study provides the first integrative evidence of glyphosate as an environmental risk factor for nephrolithiasis.