RRx-001 inhibits G6PD to deplete NADPH and trigger disulfidptosis coupled with DAMP-mediated immunogenic cell death in hepatocellular carcinoma - PubMed
4 hours ago
- #disulfidptosis
- #RRx-001
- #hepatocellular carcinoma
- RRx-001 inhibits G6PD, reducing NADPH levels and triggering disulfidptosis in hepatocellular carcinoma.
- It promotes DAMP release (e.g., CRT, HMGB1, HSP70/90), leading to immunogenic cell death (ICD).
- In vivo, RRx-001 suppresses tumor growth, increases T-cell infiltration, polarizes macrophages to M1, and downregulates PD-L1.