GABAergic Gbx1 neurons of the superficial dorsal horn are critical elements of a spinal circuit for stress-induced analgesia - PubMed
4 hours ago
- #stress-induced analgesia
- #spinal circuits
- #GABAergic neurons
- GABAergic Gbx1 neurons in the superficial dorsal horn are crucial for stress-induced analgesia.
- These neurons are not significantly involved in nociception under resting conditions but are essential for swim stress-induced analgesia.
- Retrograde monosynaptic tracing shows inputs from brain areas, especially the rostral ventromedial medulla (RVM).
- Optogenetic tracing reveals that RVM inputs are inhibitory and that Gbx1 neurons inhibit projection neurons targeting the lateral parabrachial nucleus.
- The study identifies Gbx1 neurons as key elements in a disinhibitory circuit for stress-induced analgesia.