Tissue and CD4 T cell subset dependence on the amino acid transporter SLC38A1 - PubMed
4 hours ago
- #CD4+ T cells
- #immunometabolism
- #SLC38A1
- Amino acid (AA) uptake is essential for T cell metabolism and function.
- CD4+ T cell subset and tissue-specific dependencies on the AA transporter SLC38A1 (SNAT1) were identified through in vitro and in vivo CRISPR screens.
- SLC38A1 is critical for Th1 cell-driven experimental autoimmune encephalomyelitis (EAE) and inflammatory bowel disease but dispensable for Th17 cell-driven EAE and lung inflammation.
- SLC38A1 deficiency reduces mTORC1 signaling and glycolytic activity in Th1 cells, affecting glutamine uptake, hexosamine biosynthesis, and redox regulation.
- Pharmacological inhibition of SLC38 transporters delays Th1-mediated EAE without impacting lung inflammation.
- Findings suggest CD4+ T cells have subset- and tissue-specific nutrient transporter dependencies, offering potential for selective immunotherapies.