Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses - PubMed
2 days ago
- #NSCLC
- #Brain Metastasis
- #Immunotherapy
- Brain metastasis in NSCLC leads to poor prognosis and reduces efficacy of immune checkpoint inhibitors (ICIs).
- Single-cell RNA sequencing reveals distinct immune landscapes in primary tumors vs. brain metastases.
- Brain metastases show immunosuppressive reprogramming, including HSP70-high T cells and PLTP�� macrophages.
- Memory T cells and cDC2-like dendritic cells are depleted in brain metastases.
- A seven-gene brain metastasis-derived immune signature (BMIS) is linked to ICI response and survival.
- BMIS provides complementary information to tumor mutational burden for immunotherapy outcomes.