Cyclophilin A stabilizes the capsid protein p72 to facilitate African swine fever virus replication - PubMed
5 days ago
- #Cyclophilin A
- #African swine fever virus
- #Viral replication
- African swine fever virus (ASFV) is a significant threat to the global swine industry.
- The capsid protein p72 is a major structural component of ASFV, making up about one-third of the virion mass.
- Host cyclophilin A (CypA) stabilizes p72 by reducing its ubiquitination and preventing proteasomal degradation.
- CypA interacts with p72 via its hydrophobic cavity, and this interaction is crucial for p72 stability.
- Inhibition of CypA disrupts viral factory formation and virion assembly by decreasing p72 accumulation.
- CypA is identified as a potential target for antiviral strategies against ASFV.