Mast-cell derived nerve growth factor drives ILC2 pro-tumoral functions in bladder cancer - PubMed
9 hours ago
- #ILC2
- #bladder cancer
- #NGF
- Mast-cell derived nerve growth factor (NGF) drives pro-tumoral functions of ILC2s in bladder cancer.
- ILC2s express the NGF receptor TrkA and respond to NGF by secreting type-2 cytokines.
- NGF-producing mast cells in the tumor microenvironment activate ILC2s, inducing regulatory T cells (Tregs) and fostering tumor growth.
- NGF levels inversely correlate with survival in ILC2-rich bladder tumors.
- In vivo, TrkA inhibition improves survival in tumor-bearing mice and enhances response to immune checkpoint blockade (ICB).
- Targeting TrkA+ ILC2s could be a therapeutic strategy, especially for ICB-resistant patients.