YTHDF3 facilitates DNA damage response by recognizing METTL3-mediated m6A modification to promote chemotherapy resistance in glioblastoma - PubMed
3 hours ago
- #DNA damage response
- #Glioblastoma
- #Chemotherapy resistance
- YTHDF3 plays a key role in DNA damage response (DDR) in glioblastoma (GBM) by recognizing METTL3-mediated m6A modifications.
- Elevated YTHDF3 levels correlate with poor clinical outcomes in GBM patients.
- Temozolomide (TMZ) treatment increases m6A modification, enhancing YTHDF3-mediated DNA damage repair.
- Knockdown of METTL3 reduces m6A modification and suppresses DDR core factors mediated by YTHDF3.
- YTHDF3 promotes translation of DDR genes (BRCA1, RAD51, RIF1, 53BP1) via m6A methylation, activating HR and NHEJ repair pathways.
- The study highlights YTHDF3's role in chemoresistance and suggests potential therapeutic targets for GBM.