Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities - PubMed
4 hours ago
- #senolytics
- #cataract
- #cellular senescence
- Lens epithelial cells (LECs) senescence is a key mechanism in cataract formation, driven by stressors like oxidative damage, UV radiation, and metabolic disturbances.
- Senescent LECs exhibit cell cycle arrest, SASP development, and impaired autophagy, disrupting lens homeostasis and promoting inflammation.
- Emerging therapies include senolytics (e.g., Dasatinib, Quercetin) to eliminate senescent cells and senomorphics (e.g., Metformin, Rapamycin) to modulate SASP.
- Challenges remain in ocular drug delivery, but targeting LEC senescence offers new, biologically informed approaches for cataract management.
- Future strategies may shift from surgical intervention to preventive, disease-modifying treatments focusing on cellular senescence.