Evaluating the 2023 Mexican Dietary Guidelines for Type 2 Diabetes Prevention: A Target Trial Emulation in Mexican Women - PubMed
4 hours ago
- #Women's Health
- #Type 2 Diabetes Prevention
- #Mexican Dietary Guidelines
- The 2023 Mexican Dietary Guidelines were revised to promote healthy and sustainable diets, but their impact on type 2 diabetes (T2D) prevention was unexamined.
- A target trial emulation within the Mexican Teachers Cohort estimated the 9-year risk of T2D under an intervention adopting the Guidelines compared to usual diet.
- Participants were women aged ≥40 years without prior T2D, cardiovascular disease, or cancer between 2008-2010.
- Due to low baseline adherence, thresholds were adapted so that ≥10% of the population met each recommendation.
- Among 11,307 eligible participants (mean age 46.0 years), 636 developed T2D over 9 years.
- The estimated 9-year risk of T2D was 8.44% under usual diet and 7.11% under the intervention (risk ratio 0.84; 95% CI: 0.61, 1.15).
- Findings suggest a modest potential benefit if all participants had adhered to the adapted Guidelines at baseline compared with no intervention.
- The 95% confidence intervals indicate data are compatible with a small benefit, no effect, or a slight increase in risk.