Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota-bile acid-hepatic FXR signaling - PubMed
3 hours ago
- #anthocyanins
- #hepatic steatosis
- #gut microbiota
- Dietary anthocyanins, specifically Cy-3-G, reduce hepatic triglyceride accumulation in aging mice.
- Hepatic FXR signaling is identified as the primary mediator of Cy-3-G's lipid metabolism improvements.
- Limosilactobacillus reuteri, expanded by Cy-3-G, increases bile salt hydrolase activity and reduces FXR-inhibitory tauro-β-MCA.
- Fecal microbiota transfer and L. reuteri supplementation confirm its role in improving hepatic steatosis.
- Cy-3-G mitigates age-related MASLD by reshaping bile acid composition and activating hepatic FXR signaling.