Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability - PubMed
7 hours ago
- #Oxidative stress
- #Ribosomal mutation
- #B-cell leukemia
- Mutant ribosomal protein RPS15 (S138F) drives B cell malignancy.
- Mutation causes ribosome biogenesis defects, altered translation, oxidative stress, and DNA damage.
- Induces p53-dependent response leading to initial hypo-proliferation.
- Aged mice with mutation develop B-cell leukemia (37% penetrance) with increased Myc activity.
- Translational rewiring and genomic instability enable acquisition of additional mutations (e.g., TP53 deletion).
- Mutation overcomes anti-cancer barriers to trigger tumorigenesis.