Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice - PubMed
4 days ago
- #mental health
- #dietary AGEs
- #ferroptosis
- Dietary advanced glycation end products (AGEs) combined with chronic restraint stress induce anxiety-like and depression-like behaviors in male mice.
- Combined exposure disrupts gut microbiota homeostasis, induces inflammation, and shifts tryptophan metabolism towards the kynurenine pathway.
- Elevated levels of kynurenine (KYN) and 3-hydroxykynurenine (3-HK) lead to neuronal ferroptosis in the hippocampus.
- IDO1 inhibitor 1-methyltryptophan (1-MT) restores tryptophan-kynurenine pathway disturbances and inhibits neuronal ferroptosis.
- Ferroptosis inhibitor ferrostatin-1 restores neuronal ferroptosis but does not affect the tryptophan-kynurenine pathway.
- KYN and 3-HK induce ferroptosis in hippocampal neuron cell lines, consistent with in vivo results.
- Pathological processes involve gut microbiota disruption, inflammation, and neurotoxic metabolite accumulation via the gut-brain axis.