Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms - PubMed
19 hours ago
- #RUNX transcription factors
- #metabolic disease
- #adipose thermogenesis
- RUNX1 and RUNX2 act as transcriptional barriers to thermogenic adipocyte differentiation and activation.
- Their expression is suppressed by thermal stress and linked to negative metabolic outcomes.
- Genetic deletion of RUNX1 or RUNX2 promotes beige fat formation but affects systemic metabolism differently in male mice.
- Overexpression of RUNX1/2 inhibits thermogenic gene programs and reduces adipocyte activation.
- RUNX1 recruits HDAC1 to epigenetically silence thermogenic genes, while RUNX2 uses phase-separation for repression.
- Pharmacological inhibition of RUNX1/2 boosts adipose thermogenesis and improves energy metabolism, suggesting therapeutic potential.