In vivo CAR-Tfh cell reprogramming restores tolerance in a mouse model of autoimmune hepatitis - PubMed
3 hours ago
- #immune tolerance
- #CAR-T cells
- #autoimmune hepatitis
- CAR-Tfh cell reprogramming restores immune tolerance in autoimmune hepatitis (AIH) mouse models.
- Engineered CAR-Tfh cells suppress T cells, B cells, and dendritic cells (DCs) to restore immune homeostasis.
- Self-amplifying RNA encoding Foxp3 and CYP2D6-specific CAR is delivered via lipid nanoparticles.
- CAR-Tfh cells localize to the liver, recognize CYP2D6-expressing hepatocytes, and suppress pathogenic immune responses.
- The approach provides a potential therapeutic framework for AIH and related autoimmune diseases.