Longitudinal Changes in Cardiometabolic Risk Factors are Associated with Changes in Liver Stiffness in Adults with MASLD - PubMed
6 days ago
- #liver stiffness
- #cardiometabolic risk factors
- #MASLD
- Longitudinal changes in cardiometabolic risk factors (CMRFs) are associated with changes in liver stiffness in adults with MASLD.
- Improvements in CMRFs, such as reductions in A1c and weight, are linked to improvements in liver stiffness measurement (LSM).
- Worsening CMRFs, except triglycerides and HDL, are associated with increased liver stiffness.
- The study included 1,417 participants with biopsy-proven MASLD and sequential vibration-controlled transient elastography (VCTE) exams.
- Annual changes in CMRFs were found to correlate with clinically relevant changes in LSM, CAP, and liver histology.
- Guideline-directed treatment of metabolic comorbidities in MASLD can influence disease progression and liver health.
- The findings support the importance of managing metabolic dysfunction to impact liver disease trajectory.