L1CAM Promotes the Infiltrative Properties of Patient-Derived Glioblastoma Cells - PubMed
3 days ago
- #cell motility
- #L1CAM
- #glioblastoma
- L1CAM is involved in cell adhesion, migration, and neural development.
- L1CAM-high glioblastoma (GBM) cells show increased motility on laminin compared to L1CAM-low cells.
- Anti-L1CAM antibody suppresses migration of L1CAM-high GBM cells, while ectopic L1CAM expression enhances migration in L1CAM-low cells.
- L1CAM-positive GBM cells preferentially migrate on laminin, indicating L1CAM-dependent haptotaxis.
- Forced L1CAM expression reduces retrograde actin flow velocity and promotes adhesion-clutch formation.
- In vivo, GBM cells with L1CAM overexpression display greater infiltrative capacity.
- Targeting L1CAM may suppress GBM cell infiltration and improve treatment outcomes.