Cellular reprogramming beyond pluripotency - PubMed
4 hours ago
- #cellular reprogramming
- #aging
- #rejuvenation
- Aging is now considered a modifiable process.
- Transient expression of reprogramming factors can reverse molecular hallmarks of aging while preserving somatic cell identity.
- Partial reprogramming rejuvenates tissues, restores regenerative capacity, and extends lifespan without tumorigenic risks.
- Genetic and chemical strategies for partial reprogramming are summarized.
- Tissue-specific effects of partial reprogramming in vivo are discussed.
- Implications for tissue regeneration and age-related disease are evaluated.
- Key challenges for clinical translation include safety, delivery strategies, and temporal control of reprogramming.