Nuclear receptors in age-related diseases: from mechanisms to drug discovery - PubMed
4 hours ago
- #nuclear receptors
- #drug discovery
- #aging
- Nuclear receptors (NRs) are ligand-activated transcription factors that regulate physiological processes like development, metabolism, and homeostasis.
- Activation of specific NRs (e.g., PXR, FXR, CAR) can modulate aging hallmarks such as cellular senescence, inflammation, and autophagy.
- Dysregulation of NR signaling accelerates aging and contributes to age-related disorders like metabolic and neurodegenerative diseases.
- NRs are promising therapeutic targets for mitigating aging and developing interventions for age-related diseases.
- The review summarizes NR roles in aging hallmarks, their mechanisms in diseases, and evaluates therapeutic strategies targeting NR pathways.