HBsAg Quantification-Based Models for Predicting Hepatocellular Carcinoma Risk in Nucleos(t)ide Analogs-Experienced Patients With Chronic Hepatitis B: The HBsAg-HCC Score - PubMed
4 hours ago
- #Chronic Hepatitis B
- #Risk Prediction
- #Hepatocellular Carcinoma
- Study introduces the HBsAg-HCC Score, a novel model incorporating HBsAg quantification to predict hepatocellular carcinoma (HCC) risk in nucleos(t)ide analogs-experienced patients with chronic hepatitis B (CHB).
- Developed using a retrospective training cohort (n=1190) and validated prospectively (n=506), the model identifies five independent risk factors: higher HBsAg levels, older age, male sex, hypoproteinaemia, and elevated APRI.
- The HBsAg-HCC Score demonstrated strong predictive performance with 3-/5-/7-year AUCs of 0.867/0.872/0.871 in training and 0.784/0.780/0.777 in validation, outperforming existing tools (PAGE-B, mPAGE-B, aMAP) and offering improved risk stratification by addressing limitations of conventional models.