Stress and sleep: Novel insights into stress-related sleep disorders from EEG features to neural circuitry - PubMed
7 hours ago
- #Sleep EEG
- #Neural Circuitry
- #Stress
- Stress-related sleep disorders are linked to psychiatric conditions like PTSD and MDD, with sleep disturbances often emerging before affective symptoms.
- Current clinical assessments may miss subtle neurophysiological changes, highlighting the need for specific EEG features (e.g., sleep spindles, slow-wave activity, REM theta rhythms) as potential biomarkers.
- Acute and chronic stress differentially alter oscillatory patterns, with decoupling of events like the slow oscillation-spindle complex possibly driving emotional dysregulation.
- Underlying neural mechanisms involve dysregulation in stress-responsive systems (HPA axis, LC-NE system) interacting with sleep-wake networks, compromising sleep homeostasis and emotional memory.
- Translational opportunities include targeting neural oscillations through pharmacological or neuromodulatory interventions to restore sleep and reduce psychiatric risks.