Natural products modulating MAPK for CRC treatment: a promising strategy - PubMed
8 days ago
- #MAPK pathway
- #colorectal cancer
- #natural products
- Colorectal cancer (CRC) is a common malignant tumor linked to genetics, immunity, inflammation, and abnormal signaling pathways.
- MAPK, a Ser/Thr kinase, regulates cell proliferation, differentiation, apoptosis, angiogenesis, and tumor metastasis.
- MAPK activation is highly correlated with CRC risk, making it a potential therapeutic target.
- Natural products show promise in modulating MAPK-related proteins for CRC treatment.
- A review of 47 studies from 2010-2024 highlights natural products targeting MAPK pathways (ERK, P38, JNK) for CRC therapy.