Preclinical models of breast cancer metastasis: strengths, limitations, and clinical relevance - PubMed
4 hours ago
- #breast cancer
- #metastasis
- #preclinical models
- Breast cancer metastasis is a leading cause of mortality.
- Animal models help study metastasis but have gaps, especially for heterogeneous diseases like breast cancer.
- Reviewed models include mouse models (mutagen-induced, genetically engineered), syngeneic/xenograft models, patient-derived xenografts, and rat/zebrafish models.
- Models are evaluated based on their ability to recapitulate metastasis stages, organ-specific tropism, and tumor-microenvironment interactions.
- These models are crucial for preclinical drug testing and personalized therapy.
- The review aims to guide researchers in selecting the most suitable preclinical model for metastasis studies.