Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer - PubMed
12 hours ago
- #metastasis suppression
- #breast cancer
- #mRNA stability
- Integrative analysis reveals mRNA stability regulation significantly influences gene expression variability in breast cancer.
- Development of GreyHound, a multimodal deep-learning framework, identifies RBPs and their regulons affecting mRNA stability.
- RBMS3 depletion leads to transcript destabilization, poor clinical outcomes, and increased metastatic potential in breast cancer.
- In vivo studies confirm RBMS3-mediated regulation of TXNIP mRNA stability suppresses metastasis in breast cancer.
- The study highlights the importance of posttranscriptional mechanisms in understanding breast cancer progression.