A controllable human spinal cord model with full dorsoventral patterning - PubMed
7 hours ago
- #microfluidics
- #spinal cord model
- #dorsoventral patterning
- Researchers developed a human spinal cord model called μSCLSs using hPSCs and microfluidic gradients.
- The model recapitulates complete dorsoventral patterning with human-specific transcriptional signatures.
- A previously unrecognized RA-BMP signaling crosstalk was uncovered, clarifying RA's role in spinal cord patterning.
- The study demonstrates lineage-specific ventral migration of neural crest cells in response to chemoattractants.
- This controllable model offers a powerful system for studying human spinal cord development, neural crest biology, and disease modeling.