Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of rat cerebellar Purkinje cells - PubMed
4 hours ago
- #synaptic suppression
- #GPR55
- #cannabinoid receptor
- GPR55, a non-canonical cannabinoid receptor, suppresses synaptic transmission in rat cerebellar Purkinje cell axon terminals, similar to CB1 receptors but through a distinct mechanism.
- Activation of GPR55 reduces transmitter release without altering presynaptic action potential waveform or calcium influx, but by making many calcium-responsive synaptic vesicles insensitive to calcium influx.
- This mechanism leads to a substantial reduction in the readily releasable pool of vesicles, identifying a unique presynaptic suppression pathway by an atypical cannabinoid receptor.