EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway - PubMed
8 hours ago
- #DNA repair
- #immunotherapy
- #colorectal cancer
- EEPD1 downregulation inhibits homologous recombination repair, impairing colorectal cancer cell growth and metastasis.
- EEPD1 deficiency increases genomic instability, leading to cytosolic DNA accumulation and cGAS-STING pathway activation.
- Activation of cGAS-STING promotes dendritic cell maturation, M1 macrophage polarization, and enhanced antigen presentation.
- Enhanced immune activation results in robust CD8+ T cell cytotoxicity against colorectal cancer.
- Targeting EEPD1 sensitizes colorectal cancer to anti-PD1 immunotherapy, potentially overcoming resistance to immune checkpoint blockade.