CALHM5 deficiency alleviates aortic aneurysm by regulating smooth muscle calcium homeostasis - PubMed
4 hours ago
- #calcium homeostasis
- #aortic aneurysm
- #ion channel
- CALHM5 is an ion channel found in the smooth muscle cells of both humans and mice.
- Deficiency in CALHM5 alleviates aortic aneurysm by regulating calcium homeostasis in smooth muscle cells.
- CALHM5 deficiency suppresses transcription of the L-type calcium channel subunit via downregulation of cAMP-response element binding proteins.
- This suppression leads to reduced blood vessel contractility and decreased blood flow.
- CALHM5 expression is downregulated in aortic aneurysm patients' smooth muscle tissues.
- In mice, CALHM5 deficiency mitigates abdominal aortic aneurysm development partly through stimulated smooth muscle cell proliferation.
- CALHM5 is identified as a regulator of smooth muscle contraction and a potential therapeutic target for aortic aneurysms.