SEMA3C/PLXND1 Interaction Regulates Collagen Metabolism in Keloid Fibroblasts via the TGF-β1 Signaling Pathway - PubMed
3 hours ago
- #SEMA3C/PLXND1 axis
- #keloid fibrosis
- #TGF-β1 signaling
- The study investigates the SEMA3C/PLXND1 pathway's role in keloid fibrosis via TGF-β1 signaling.
- Single-cell RNA sequencing (scRNA-seq) was performed on 8 keloid and 8 normal skin samples.
- Enhanced intercellular communication was observed in keloids, especially among fibroblasts.
- SEMA3C (secreted by Schwann cells) and PLXND1 (overexpressed in keloid fibroblasts) were identified as a key ligand-receptor pair.
- SEMA3C upregulated collagen I/III, fibronectin, and TGF-β1 expression in a dose-dependent manner.
- PLXND1 knockdown or TGF-β1 inhibition attenuated fibrotic effects, confirming the pathway's role.
- The study is the first to show SEMA3C/PLXND1 drives keloid fibrosis via TGF-β1 activation.
- Targeting the SEMA3C/PLXND1 axis could be a promising therapeutic approach for keloids.