Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database -
5 days ago
- #Panic Attacks
- #Pharmacovigilance
- #Fluoroquinolones
- Fluoroquinolones are associated with CNS adverse events like anxiety and depression.
- Recent case reports suggest a link between fluoroquinolone use and panic attacks.
- Systematic review and disproportionality analysis were conducted using the FAERS database.
- Compared to azithromycin, fluoroquinolones showed a 6-fold increase in panic attack reports.
- Compared to trimethoprim/sulfamethoxazole, fluoroquinolones showed a 12-fold increase in panic attack reports.
- The prevalence of panic attacks in clinical trials ranged from 0.46% to 1.76%.
- Results were consistent across different statistical analyses, including Bayesian methods.
- The study highlights the need for further pharmacoepidemiological validation.
- Causal relationships cannot be determined due to reliance on spontaneous reports.