Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial-mesenchymal transition and pulmonary niche formation of breast cancer - PubMed
5 hours ago
- #extracellular vesicles
- #lung metastasis
- #breast cancer
- Extracellular vesicles (EVs) play a crucial role in breast cancer lung metastasis by facilitating cell-cell communication.
- Tumor-derived EVs promote epithelial-mesenchymal transition (EMT) in breast cancer cells, enhancing their migratory and invasive abilities.
- EVs act as a 'vanguard' to precondition the lung microenvironment, establishing a pre-metastatic niche that supports cancer colonization.
- The review proposes that distinct EV subpopulations synergistically regulate both EMT and niche formation, rather than single vesicles performing multiple tasks.
- Future research should focus on EV heterogeneity to develop precise EV-based interventions for metastasis prevention.