Targeting REV-ERBα/BNIP3 axis attenuates pulmonary arterial hypertension by repressing mitophagy in mice - PubMed
19 hours ago
- #pulmonary arterial hypertension
- #REV-ERBα
- #mitophagy
- REV-ERBα deficiency in vascular smooth muscle cells (VSMCs) worsens pulmonary arterial hypertension (PAH) in mice, while its activation or overexpression alleviates the disease.
- The REV-ERBα agonist improves established PAH even when administered at a late stage, highlighting its therapeutic potential.
- REV-ERBα directly represses Bnip3 transcription, which inhibits BNIP3-driven mitophagy, improves mitochondrial function in hypoxic pulmonary artery smooth muscle cells (PASMCs), and protects against PAH.