Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing - PubMed
4 hours ago
- #lipid nanoparticles
- #gene editing
- #mRNA delivery
- Development of dexamethasone (DEX) prodrug ionizable lipids (DPILs) for safe and effective mRNA delivery.
- Creation of the SHIELD LNP platform, with DEX-SPM-CP10 SHIELD LNP as the lead formulation, reducing proinflammatory cytokines while maintaining high mRNA delivery efficiency.
- Demonstrated universality of the SHIELD platform by enhancing mRNA expression and reducing inflammation in LNPs targeting various organs.
- Successful application in gene editing therapy (ABEmax mRNA and sgRNA) and protein replacement therapy with minimal immunogenicity.
- SHIELD platform shows potential to expand therapeutic applications of mRNA-based therapies due to its safety and efficiency.